Bronchiectasis Managing Inflammation | Rethinkbronchiectasis

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Neutrophils and neutrophil serine proteases (NSPs) help protect the lungs but can contribute to neutrophilic inflammation in bronchiectasis.^1–5

This can lead to severe consequences, including disease progression, lung destruction and exacerbations.^1,2,5,6

What is bronchiectasis?

Bronchiectasis is a chronic condition with unpredictable exacerbations and varied symptoms.

Get to know bronchiectasis

Impact of exacerbations

Exacerbations significantly increase mortality risk and affect long-term patient outcomes.

Learn about exacerbation risks

Vicious vortex

Bronchiectasis progresses through a cycle of infection, inflammation, impaired clearance and lung damage.

Explore the cycle

Neutrophilic inflammation

Neutrophils drive chronic inflammation in bronchiectasis, worsening disease severity over time.

Dive into airway inflammation

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Resources for your patients

BE Symptom Snapshot

Strengthen the communication with your patients by facilitating the documentation of exacerbations

Download

Doctor Discussion Guide

Enable your patients to answer the questions that really matter to them

Download

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Dente FL, Bilotta M, Bartoli ML, et al. Neutrophilic bronchial inflammation correlates with clinical and functional findings in patients with noncystic fibrosis bronchiectasis. Mediators Inflamm. 2015;2015:642503.
Effah CY, Drokow EK, Agboyibor C, et al. Neutrophil-dependent immunity during pulmonary infections and inflammations. Front Immunol. 2021;12:689866.
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Polverino E, Dimakou K, Hurst J, et al. The overlap between bronchiectasis and chronic airway diseases: state of the art and future directions. Eur Respir J. 2018;52(3):1800328.
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Chan ED, Wooten WI III, Hsieh EWY, et al. Diagnostic evaluation of bronchiectasis. Respir Med X. 2019;1:100006.
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Bedi P, Davidson DJ, McHugh BJ, et al. Blood neutrophils are reprogrammed in bronchiectasis. Am J Respir Crit Care Med. 2018;198(7):880–890.
Chalmers JD, Chotirmall SH. Bronchiectasis: new therapies and new perspectives. Lancet Respir Med. 2018;6(9):715–726.
Polverino E, Goeminne PC, McDonnell MJ, et al. European Respiratory Society guidelines for the management of adult bronchiectasis. Eur Respir J. 2017;50(3):1700629.