Exacerbations can have serious consequences for patients¹⁶

Compared to patients with no exacerbations, patients who have experienced an exacerbation have nearly double the risk for another, and the risk increases with subsequent exacerbations.¹⁶

Increased risk of 5-year all-cause mortality*^,16

Two icons representing the mortality risk in patients with 2 and 3 or more exacerbations per year

+0%

2 exacerbations per year

+0%

≥3 exacerbations per year

*Compared with patients without exacerbations, in a study of 2,527 patients with bronchiectasis from 10 clinical centres in Europe and Israel.

Identifying an exacerbation

A consensus definition from an expert committee defines an exacerbation in clinical research as a patient experiencing the worsening of 3 or more of these symptoms over 48 hours, requiring a change in treatment:¹⁷

Cough

Fatigue: An icon representing an eye closed, looking tired and weary

Fatigue and/or malaise

Dyspnea: An icon representing a person appearing to struggle to breathe

Breathlessness and/or exercise intolerance

Hemoptysis (Coughing Up Blood): An icon representing a person coughing up blood into a tissue

Haemoptysis

Sputum volume and/or consistency

Daily Sputum Production: An icon representing a person coughing up mucus or phlegm into a tissue

Sputum purulence

Preventing exacerbations can help make a positive impact on patients both physically and mentally.^7,16

It’s important that patients are educated about the consequences of exacerbations and the appropriate actions to take, including when to seek medical help and report them to their treating physician.

Exacerbations can have serious consequences for patients16

Compared to patients with no exacerbations, patients who have experienced an exacerbation have nearly double the risk for another, and the risk increases with subsequent exacerbations.16

Identifying an exacerbation

A consensus definition from an expert committee defines an exacerbation in clinical research as a patient experiencing the worsening of 3 or more of these symptoms over 48 hours, requiring a change in treatment:17

Preventing exacerbations can help make a positive impact on patients both physically and mentally.7,16

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References

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Exacerbations can have serious consequences for patients¹⁶

Compared to patients with no exacerbations, patients who have experienced an exacerbation have nearly double the risk for another, and the risk increases with subsequent exacerbations.¹⁶

A consensus definition from an expert committee defines an exacerbation in clinical research as a patient experiencing the worsening of 3 or more of these symptoms over 48 hours, requiring a change in treatment:¹⁷

Preventing exacerbations can help make a positive impact on patients both physically and mentally.^7,16