




Neutrophils & inflammation in bronchiectasis
Dysregulated neutrophils are a main driver of airway inflammation.1,5

How neutrophils contribute to bronchiectasis18–20
- Neutrophils release neutrophil serine proteases (NSPs), which drive airway inflammation
- Overactive neutrophil elastase (NE) contributes to chronic inflammation, tissue damage and increases the risk of future exacerbations
- Limited treatments exist to adequately control this inflammation in bronchiectasis
What’s driving bronchiectasis progression

Bronchiectasis management focuses on21
- Controlling infections
- Clearing airways
- Mitigating impact of chronic lung disease
Managing bronchiectasis through inflammation control