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Neutrophils & inflammation in bronchiectasis​

Dysregulated neutrophils are a main driver of airway inflammation.1,5

Chronic Airway Inflammation, Primary Neutrophilic: An icon representing inflamed airways in the lungs with an emphasis on neutrophils

How neutrophils contribute to bronchiectasis18–20

  • Neutrophils release neutrophil serine proteases (NSPs), which drive airway inflammation
  • Overactive neutrophil elastase (NE) contributes to chronic inflammation, tissue damage and increases the risk of future exacerbations​
  • Limited treatments exist to adequately control this inflammation in bronchiectasis​

What’s driving bronchiectasis progression

Icon of lungs with a hand underneath, symbolizing lung care or respiratory support

Bronchiectasis management focuses on21

  • Controlling infections​
  • Clearing airways​​
  • Mitigating impact of chronic lung disease

Managing bronchiectasis through inflammation control