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How the 4 drivers of bronchiectasis contribute to disease progression1

Bronchiectasis has been characterised in scientific literature as a vicious cycle or vortex consisting of 4 primary drivers: Chronic airway infection, chronic airway inflammation – primarily neutrophilic, impaired mucociliary clearance and lung destruction.1,14

A graphic showing the vicious vortex, an interconnected network between four icons, representing chronic airway inflammation, chronic airway infection, impaired mucociliary clearance and lung destruction
Chronic Airway Inflammation: An icon representing inflamed airways in the lungs

Chronic airway infection

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Chronic Airway Inflammation, Primary Neutrophilic: An icon representing inflamed airways in the lungs with an emphasis on neutrophils

Chronic airway inflammation, primarily neutrophilic

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Impaired Mucociliary Clearance: An icon representing mucus buildup in the airways of the lungs

Lung destruction

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Lung Destruction: An icon representing damaged or scarred lung tissue

Impaired mucociliary clearance

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Explore the 4 drivers of bronchiectasis

Within the self-perpetuating cycle of bronchiectasis, each driver can lead to the worsening of the others and contribute to progressive lung damage and exacerbations.1,5